HIGHLIGHTS 1. Principles of accelerated ageing and testing methodologies 2. Correlation between accelerated and real-time ageing studies 3. Seal integrity and material compatibility assessments 4. Regulatory expectations aligned with ISO 11607. Contact: medicalplastics@gmail.com
Sterilization of medical polymers often alters their physical, chemical, and structural properties, significantly affecting biocompatibility and in vivo performance. Common methods—autoclaving, gamma radiation, ethylene oxide (EtO), and H₂O₂ plasma—can cause chain scission, crosslinking, polymer degradation, or surface toxicity. Proper sterilization must balance microbial elimination with maintaining material structural integrity, surface morphology, and minimizing cytotoxic, leachable byproducts.
Ultra-high molecular weight polyethylene (UHMWPE) is a biomaterial widely used as part of prostheses that require articulating surfaces, such as knee endoprostheses, for its excellent mechanical qualities. The Ultra-High Molecular Weight Polyethylene (UHMWPE) market for knee implants is experiencing robust growth, driven by an aging population, increased joint replacement surgeries, and........
