A TECHNO-ECONOMIC NEWS MAGAZINE FOR MEDICAL PLASTICS AND PHARMACEUTICAL INDUSTRY
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Technology

POLYMERIC PRESSURE SENSITIVE ADHESIVES FOR MEDICAL APPLICATIONS

-By Mr. P A Mahanwar & Ms. Farhana Yasmeen, University Department of Chemical Technology, Matunga, Mumbai 

3. Adhesive tapes :  

Hospital uses of pressure sensitive adhesives involve many general, as well as specific, purpose tapes.  Coated or uncoated cotton fabrics was used for early hospital tapes.  These backings are still used for strapping tapes that require higher tensile strength.  Synthetic fabrics, non-woven fabrics and films were later introduced as backings for hospital tapes.

Tapes are used for many different applications in the hospital and health areas, but basically perform one of the two functions.  Tapes are used either to pull something to place and restrict movement, as in strapping applications, or are used to hold something in place such as wound dressings.

Kitazaki et.al10 have studied adhesive tapes prepared by coating an adhesive tapes prepared by coating an adhesive agent on an aerobic and scratchable non woven fabrics mad of polyurethane fibers having average filament diameter of 7-15 micrometer and first aid bandages are prepared from the adhesive tapes.  Non woven fabrics have ratios of 50% tensile strength at machine direction/ that at transverse direction = 1.10-2.00.  the adhesive tapes and first aid bandages shown good biocompatibility and fitting properties.

Kitazaki et.al11 have studied the tapes have bases showing 50% tensile stress in mkachine direction (X) and that in transverse direction (Y) satisfying X, Y<24 N/19mm (at 23 C) and Y/X=1.10-2.00.  Here flexible PVC film was coated with an adhesive comprising natural rubber 30, styrene-isoprene-styrene rubber 10, liquid isoprene rubber 10, alicyclic petroleum resin 29, terpene resin 20, and antioxidant 1wt % to give a first aid adhesive plaster showing adhesive strength (to bakelite) 7.9 N/19 mm, probe tack 6.2 N/5mm, holding power (1.0 kg. 15 min) 0.8 mm/10 X 20mm, and Y 12.0 N/19mm.  The plaster fitted well with a finger.

Oka et.al12 have studied the adhesive tapes for medical use comprising of a support layer and an adhesive layer containing alkyl (methyl) acrylate polymer and organic peroxides [such as 1,1-bis (tert-butylperoxy)-2-methylcyclohexane] with number addition of crosslinking agents.  The adhesives are painted on the support layer and heated at a temperature (90-120)0. 

Masoaki et. Al13 have patented the pharmaceutical tapes with low skin irritancy comprising.  A support lawyer and an adhesivie layer containing alkyl (meth) acrylate-PVP copolymer rubbers or their copolumersm, liquid substances [miscible with the acrylic copolymers] and active ingredients, the preparations showed excellent transdermal and transmucosal permeability and adhesiveness.

One of the patent reports adhesive tapes formulation prepared by coating an adhesive layer on a porous polutetrafluoroethylene film [the filem is subjected to single and aw liquid absorbing pad.  The preparation were non irritating and suitable for applications in the joint area14.

Marikawa et. al15 have studied the water and oil-absorbing wound dressings showing good biocompatibility and wound healing activities comprises a film or sheet type polymer base layer and an adhesive layer containing poly a-amino acid particles having average particles size 0.1-100 um.

Takanori et. al16 have studied the pharmaceutical tapes showing improved skin adherence and absorption having a base layer and a porous polyester elastomer membrane layer containing active ingredients such as diclofenac.  It is reported that porosity of the polyelastomer membrane is 10-95%.  The preparation caused no skinirritation.

Lranaka et.al17 have studied a wa ter repelling adhesive tapes comprise a water repellent-treated, nonwoven fabric support layer and an adhesive layer containing soluble and insoluble polymers, adhesives layer containing soluble and insoluble polymers, adhesives agents, polyols, crosslinking agents and water.

4. Surgical drapes :

Surgical drapes are divided into two main types, each of which used pressure sensitive adhesive.  The first type is the incise drape which is a large sheet of thin, transparent film with a smaller, continous section of pressure sensitive adhesive, the excess film providing handles.  In use, the release liner is removed and the adhesive is applied to the sterilized skin of the surgical patient.  The film substrates used for incise drapes are polyurethance, copolyester, vinyl and polyethylenes.  Acrylic or vinyl pyrollidone-based adhesive is transfer coated to the film.  Adhesives mixed with antimicrobial agents are used in the construction of incise drapes as well as the thinfilm wound care products.  The homogenous mixture of any broad-spectrum antimicrobial agent with an adhesive is protected by a 1982 patent assigned to 2M while constructions using solids such as silver sulfadiazine are covered by 1984 Smith and Nephew patent.  A separate 1982 3M patents covers the use of iodine.  The use of polyhexamethylene biguanide salts, as incorporated particles or sprayed on the adhesive, are covered in two 1987 patents assigned to Surgikos.  Antimicrobial activity may be achieved without directly mixing the active agent with the adhesive.  In this case, a three - layer construction is used in which the antimicrobial is included in a reservior layer berween the adhesive and the backing.

The second type of surgical drape is the fenestration drape, in which a window is cut into a large sheet of fabric, film or laminate.  In manufacturing the drape, strips of tape with a release liner are bonded around the perimeter of the window.  Transfertape may be used for this apploication, but double coated tape is more common.  The double coated tape is constructed with adhesive on both sides of polyester or polyethylene film, protected with a differential silicone release liner.  The adhesive on the patient side of the tape may or may not be identical to the drape side adhesive.  Some European draopes have used doubled coated scrim rather than doublecated film.  The unwinding adhesive side of the doublecoated tape must adhere to the drape.

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